Clinical findings of triglyceride deposit cardiomyovasculopathy
نویسندگان
چکیده
Abstract Background Triglyceride (TG) deposit cardiomyovasculopathy (TGCV) is a novel cardiovascular disorder and was recently encoded as an orphan disease in Europe (ORPHA code: 565612). Defective intracellular lipolysis results TG accumulation the myocardium coronary arteries TGCV. The myocardial washout rate (WR) of iodine-123-β-methyl-p-iodophenylpentadecanoic acid (BMIPP) essential indicator to evaluate vivo, decreased WR (<10%) BMIPP one items diagnostic criteria for Purpose To clarify clinical findings TGCV including comorbid conditions laboratory findings. Methods We enrolled 234 patients who underwent scintigraphy between September 2015 July 2019. distributions each comorbidity, cardiac functions were investigated. Results In total, 104 diagnosed with definitive −1.37±10.6%. had various conditions, artery (75%), diabetes mellitus (56%), heart failure (21%). Left ventricular ejection fraction (LVEF) significantly lower than that non-TGCV (38.1±18.0% vs. 43.6±18.9%, p-value=0.026). Moreover, among those did not take lipid-lowering drugs, there no difference serum level (TGCV: n=44, 127±84.6 mg/dL, non-TGCV: n=66, 133±70.7 p-value=0.73). Conclusions showed multiple coexistence disease, mellitus, or LVEF. Serum different patients. affect directly, this result consistent pathophysiological hypothesis cytoplasm due lipase dysfunction. Funding Acknowledgement Type funding sources: None.
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2022
ISSN: ['2634-3916']
DOI: https://doi.org/10.1093/eurheartj/ehac544.1678